This study investigates the pharmacokinetic (PK) and pharmacodynamic (PD) consequences\nof shifting from Quetiapine fumarate immediate-release (IR) to extended-release (XR) formulation in\nnon-adherent schizophrenia patients. Monte-Carlo simulations using population PK and PD models\nwere implemented to predict the time course of plasma concentration and Brief Psychiatric Rating\nScale (BPRS) scores following the oral administration of 200 mg Seroquel® every 12 h and 400 mg\nSeroquel XR® every 24 h in patients experiencing dose delay, omission or doubling. Parameters\nwere computed and their distributions were compared using the Kolmogorovâ??Smirnov test. Dose\nirregularities with both formulations had different effects on plasma concentration and %reduction in\nBPRS scores from baseline. However, the odds ratio of getting a %reduction in BPRS below 14%, or\nplasma concentration exceeding 500...............
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